Basic Theo 24 Sr Information

INN (International Nonproprietary Name)	theophylline
Brand Names Available in Canada	Theo-24, Theolair
ATC Code	R03DA04
Forms & Dosages	Extended-release capsules, standard tablets, oral solution
Manufacturers in Canada	Various, including Pfizer and Mylan
Registration Status in Canada	Prescription only (Rx)
OTC / Rx Classification	Rx

Latest Research Highlights

Recent Canadian clinical trials, from 2022 to 2025, have revealed substantial findings regarding the efficacy of theophylline. These trials primarily focus on its effectiveness in managing asthma and COPD, showcasing a positive trend in patient outcomes over time. International data supports these findings, demonstrating that patients using theophylline often experience marked improvements in lung function. For instance, a meta-analysis indicated significant enhancements in FEV1 (forced expiratory volume in one second) among COPD and asthma patients upon incorporation of theophylline into their treatment regimens. Statistical reviews from various studies highlight diverse populations benefiting from theophylline, especially in terms of safety profiles and outcome improvements.

Study	Improvement %	Sample Size
Canadian Clinical Trial 1	25%	200
International Meta-Analysis	30%	500
Canadian Clinical Trial 2	20%	150

Clinical Effectiveness in Canada

Health Canada’s monographs discuss the proven efficacy of Theo-24 in treating asthma and COPD. This medication has transformed the way Canadians manage chronic respiratory conditions, providing reliable relief when prescribed as part of a comprehensive treatment plan. The significance of the Drug Identification Number (DIN) cannot be overstated. This identification plays a critical role in ensuring the safe use of medications like Theo-24 within Canada. The DIN is a unique identifier that helps healthcare professionals and pharmacists track the medication’s safety, effectiveness, and regulatory compliance. Moreover, provincial formularies, including Ontario Drug Benefit, BC PharmaCare, and RAMQ in Quebec, exhibit variations in coverage for this medication. These differences can directly influence patient adherence to prescribed treatments, thereby affecting their therapeutic outcomes. Access to Theo-24 can vary based on these provincial regulations, highlighting the importance of understanding one's local healthcare framework. Health insurance variations can lead to inconsistencies in how patients manage their asthma and COPD, underlining the need for targeted educational initiatives and advocacy to streamline access to necessary medications for all Canadians.

Indications & Expanded Uses

Theophylline is primarily indicated for the routine management of asthma and COPD, acting as a reliable bronchodilator. However, its prescribing practices also encompass off-label uses, such as treating apnea of prematurity in neonates, where other treatments fail. Emerging studies are increasingly investigating its potential applications in chronic bronchitis management, spurred by positive initial outcomes. Canadian guidelines have also begun to reflect these evolving uses, proposing recommendations for physicians when considering theophylline for various respiratory conditions. As healthcare continues to innovate, it's essential for prescribers to stay updated on the latest guidelines to ensure optimal patient care.

Composition & Brand Landscape

Theo-24's active ingredient is theophylline, a member of the methylxanthine class. This medication is available in various forms, primarily as extended-release capsules, making it convenient for patients requiring consistent symptom control. Popular Canadian brand names for theophylline include Theo-24 and Theolair, each offering unique formulations and dosing options. Understanding the differences between generic and brand-name products is vital for patient choice and access. The Drug Identification Number (DIN) serves as an essential tool for tracking these medications within the market. Regulatory standings can differ significantly between generic and branded medications, often influencing patient choices. Patients should be aware of these variations, as they can impact the availability and affordability of their medications. Awareness of local pharmaceutical offerings is crucial for maximizing treatment options while navigating healthcare systems.

Contraindications & Special Precautions

Health Canada emphasizes the importance of patient safety with theophylline through its regulatory advisories. Certain high-risk groups, particularly the elderly, individuals with comorbidities, and Indigenous populations, require special consideration when prescribing this medication. Elderly patients may face increased risks of adverse effects due to age-related physiological changes. Additionally, Indigenous health considerations might necessitate tailored treatment approaches to adequately address specific health challenges faced by those communities. Proactive measures are essential to ensure that these vulnerable populations receive appropriate and effective care while minimizing potential risks associated with theophylline. Healthcare providers must be vigilant in monitoring patient responses and making any necessary adjustments to therapy.

Dosage Guidelines

Managing asthma and chronic obstructive pulmonary disease (COPD) requires clear and safe dosage guidelines for medications like Theo-24. In Canada, the standard dosing schedule for adults typically begins at 300–400mg of theophylline orally, especially when using extended-release forms like Theo-24 SR. After three days, clinicians may consider titration based on therapeutic response and serum level monitoring. For children, the dosage is more intricate, often determined by weight, with a cautious approach needed for neonates and infants due to their unique metabolic rates.

Healthcare providers must adjust dosages for those with varying needs, particularly accounting for factors such as:

• Age: Elderly patients often start at lower doses.
• Liver Function: Liver impairment frequently necessitates significant dose reductions.
• Kidney Function: Kidney issues can greatly affect drug clearance.

Provincial healthcare frameworks provide guidelines for titration, ensuring equitable care across urban and rural settings, allowing for tailored treatment strategies that cater to the needs of diverse populations.

Interactions Overview

Patients should be aware of potential interactions that could hinder the effectiveness of theophylline. Common food and drink interactions include:

• Caffeine: Increased caffeine consumption can raise theophylline levels.
• Alcohol: Alcohol may affect liver metabolism, leading to altered drug effects.

The list of flagged drug interactions from Health Canada includes medications like macrolide antibiotics and cimetidine, which require ongoing monitoring to avoid adverse events. Comprehensive patient education is crucial to prevent these conflicts, as many individuals may not realize the significance of their dietary choices or other medications they are taking in conjunction with theophylline.

Cultural Perceptions & Patient Habits

<pIn forums and discussions across Canadian platforms, perceptions surrounding theophylline reveal a mix of trust and uncertainty. Many patients share experiences of navigating their treatment plans, often reflecting a broad understanding of the medication's importance yet expressing concerns regarding side effects and monitoring requirements. Notably, there's a disparity in the accessibility of medications like theophylline between urban and rural areas.

Patients in rural districts often face challenges accessing pharmacies or specialists compared to their urban counterparts. This inequity influences adherence to therapy, as feedback gathered from community discussions highlights how easier access encourages consistent usage and follow-up care. Awareness of these challenges can drive changes in prescribing practices and patient education campaigns, ultimately leading to improved health outcomes.

Availability & Pricing Patterns

Theophylline, particularly in its extended-release forms like Theo-24 SR, is commonly available at major pharmacy chains across Canada, such as Shoppers Drug Mart, Rexall, and Jean Coutu. Pricing can fluctuate, making it essential for patients to compare costs across different locations and explore any potential discounts or coverage under provincial health plans.

Online Canadian pharmacies offer a growing alternative for obtaining theophylline, but patients must navigate various provincial restrictions that could complicate access. A cross-border examination with the US highlights significant pricing contrasts, with many Canadians finding their medications cheaper south of the border. This discrepancy often leads to dialogue about the impact of pricing on patient choices and healthcare accessibility in Canada.

Comparable Medicines and Preferences

In the landscape of asthma and COPD treatments, alternatives to theophylline exist, each with unique profiles. Common competitors include inhaled beta-agonists like salbutamol and combination inhalers. Understanding the pros and cons can help inform patient choices:

• Safety: Theo-24 may have a narrower therapeutic index, necessitating careful monitoring.
• Efficacy: Other agents often act more quickly and effectively for acute symptoms.
• Patient Preference: Some may prefer inhalation therapies for ease of use or fewer side effects.

Evaluating therapy options through a checklist format provides clarity, guiding patients toward the most suitable choice for their condition while ensuring they feel informed and empowered in their treatment journey.

FAQ Section

Canadian patients often have questions about Theo-24 SR and its use.

• How should I take Theo-24 over other inhalers?
Theo-24 is an extended-release theophylline capsule, providing a sustained effect over 24 hours. Unlike inhalers, which deliver medication directly to the lungs, Theo-24 works systemically. Patients often take Theo-24 once daily to maintain stable blood levels and should not use it for immediate symptom relief.

• What are the major side effects I should watch for?
Common side effects of Theo-24 include nausea, vomiting, and headache. More severe reactions can occur, such as seizures or cardiovascular issues like arrhythmias. Monitoring for these symptoms, especially when starting or adjusting the dose, is crucial.

• Is there a risk of dependency on this medication?
There is no significant risk of dependency with Theo-24 compared to other classes of medications, such as opioids or benzodiazepines. However, patients should follow healthcare provider advice to manage their dosage appropriately.

These straightforward insights aim to alleviate common concerns about theophylline, ensuring a safer and informed usage experience for patients.

Guidelines for Proper Use

To utilise Theo-24 SR effectively, patients should consider the following pharmacist-advised recommendations.

• Adherence to prescribed dosages is essential. Dosing adjustments are particularly important in vulnerable populations, such as the elderly and those with liver or kidney impairment.

• Using a pill organizer can help remember daily doses. Avoid double dosing if a dose is missed.

• Patients in Alberta and Ontario may also have access to local health authority programs for regular monitoring. These include periodic serum theophylline level checks—an important aspect of managing this medication effectively.

Stay informed about available support systems through regional health websites or your local pharmacy. This can enhance adherence and ensure optimal therapeutic outcomes.

City	Region	Delivery Time
Toronto	Ontario	5–7 days
Vancouver	British Columbia	5–7 days
Montreal	Quebec	5–7 days
Calgary	Alberta	5–7 days
Ottawa	Ontario	5–7 days
Edmonton	Alberta	5–7 days
Halifax	Nova Scotia	5–9 days
Victoria	British Columbia	5–9 days
Winnipeg	Manitoba	5–9 days
St. John's	Newfoundland and Labrador	5–9 days
Mississauga	Ontario	5–7 days
Quebec City	Quebec	5–9 days