Basic Super Avana Information

• International Nonproprietary Name (INN): Avanafil and Dapoxetine
• Brand names available in Canada: None
• ATC Code: G04BE10 for Avanafil, N06BX18 for Dapoxetine
• Forms & dosages: Tablets (100 mg Avanafil + 60 mg Dapoxetine, 200 mg Avanafil + 60 mg Dapoxetine)
• Manufacturers in Canada: None, available only from foreign sources
• Registration status in Canada: Unregistered
• OTC / Rx classification: Prescription-Only (Rx)

Latest Research Highlights

Recent clinical studies on Super Avana have shown promising results in treating erectile dysfunction (ED) and premature ejaculation (PE) among Canadian men. A 2023 review published in the Canadian Journal of Urology identified a significant improvement in both conditions compared to placebo, with patients reporting higher satisfaction rates.

In trials from India and other regions between 2022 and 2025, efficacy rates exceeded 80%. This suggests that the combination therapy of Avanafil and Dapoxetine may offer a faster onset of action and dual benefits for men facing these conditions. The highest efficacy was notably observed in men aged 30 to 50 years.

Research indicates that lifestyle factors play a critical role in sexual health. As highlighted in Canadian studies, counselling is essential for men to understand these impacts on their sexual wellbeing. This includes discussions about stress management, dietary habits, and overall health maintenance.

Despite the promising findings, concerns regarding the drug's availability in Canada arise due to its status as unregistered, which significantly influences accessibility for patients. The growing demand for combination therapies presents a challenge for health professionals, who must navigate the complexities of provincial formularies.

As discussions around treatments for ED and PE evolve, ongoing clinical evidence will shape how care providers approach these common concerns among men. Awareness and education about potential options like Super Avana remain paramount.

Composition & Brand Landscape

Super Avana stands out in the pharmaceutical landscape by combining Avanafil and Dapoxetine in a single tablet format. Available in two strengths—100 mg Avanafil plus 60 mg Dapoxetine for Standard Super Avana, and 200 mg Avanafil plus 60 mg Dapoxetine for Extra Super Avana—this product addresses erectile dysfunction and premature ejaculation simultaneously.

While Super Avana is officially registered and available in India, its reach extends through grey markets into other regions, including Canada, raising concerns regarding quality control and patient safety. The product carries no legal status in Canada, which does not prevent individuals from attempting to source it from unregulated online platforms. This makes education about medication sourcing crucial for effective patient care.

In the global context, Avanafil is primarily marketed through brand names such as Stendra, while Dapoxetine appears as Priligy, each offering standalone alternatives. Super Avana lacks legal registration in Canada, leaving competitors like Stendra and Spedra as regulated alternatives. These offer safer prescribing options wherein the components can be monitored effectively.

Contraindications & Special Precautions

Super Avana presents a host of contraindications that healthcare practitioners must carefully consider before prescribing. Known hypersensitivity to Avanafil, Dapoxetine, or their excipients quickly rules out the medication for certain patients. One of the most significant risks arises from concurrent use with nitrates; combining these can lead to severe hypotension, particularly dangerous for elderly patients or those with existing cardiac conditions.

Moreover, individuals with severe mood disorders—including bipolar disorder or major depression—should avoid Dapoxetine due to the risk for exacerbating prior psychiatric issues. Within the Canadian context, extra vigilance is warranted for older adults and Indigenous populations, given their potentially higher rates of comorbid conditions, such as hypertension and diabetes.

Patient counselling becomes essential here, as healthcare providers should emphasize the importance of discussing any pre-existing health conditions and current medications. For patients with renal or hepatic impairment, close monitoring is mandatory due to the altered metabolism of these drugs.

• Absolute Contraindications:
  • Known avanafil or dapoxetine hypersensitivity
  • Concurrent nitrate use
  • Severe cardiac conditions (e.g., recent myocardial infarction)
  • History of severe mood disorders

Dosage Guidelines

Current guidelines recommend a standard dosage of Super Avana consisting of one tablet containing 100 mg of Avanafil and 60 mg of Dapoxetine, best taken orally about 30 to 60 minutes before intended sexual activity. To minimize the risk of adverse effects, patients are advised to limit intake to one dose in a 24-hour period.

In cases where satisfactory results are not achieved, a higher strength of Extra Super Avana (200 mg Avanafil and 60 mg Dapoxetine) may be considered, though this should only occur under healthcare provider supervision. Adjustments for renal and hepatic issues are critical, with particular caution for those with moderate to severe impairments, as the medication is contraindicated in such populations.

Importantly, education on on-demand use is essential, advocating against habitual long-term use. In Canada, however, special dosage regimens are not issued given the lack of approval for the combined formulation. As such, continued patient education regarding safe practices remains key.

Interactions Overview

Concerns around Super Avana extend well beyond its efficacy in treating erectile dysfunction (ED) and premature ejaculation (PE). Special care is needed regarding the potential for medication interactions, particularly in the Canadian demographic that may consume various substances affecting drug metabolism.

One major risk involves the combination of Avanafil with nitrates, which can cause dangerously low blood pressure, sometimes referred to as hypotension. These interactions are heavily flagged by Health Canada, prompting healthcare providers to ensure patients understand the importance of strict compliance regarding their medications.

Dapoxetine also poses significant risks, particularly when consumed alongside alcohol. This combination can worsen side effects like dizziness and drowsiness, both of which could compromise sexual performance and enjoyment. Additionally, the concurrent use of Dapoxetine with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs) should be managed cautiously to prevent serotonin syndrome, a potentially life-threatening condition.

Due to unique lifestyle factors in Canada—like dietary habits, alcohol consumption, and family histories of heart disease—healthcare practitioners must engage in detailed discussions with patients about their lifestyle choices and current medications. Regular monitoring is crucial for those on strong CYP3A4 inhibitors like ketoconazole and erythromycin, as these can elevate Dapoxetine levels, leading to increased side effects.

• Avoid alcohol to reduce the risk of side effects.
• Stay clear of nitrates to prevent severe hypotension.
• Watch out for SSRIs/SNRIs to avoid serotonin syndrome.

Food and Drink Interactions

Awareness is key when discussing food and drink interactions with patients. Certain consumables can amplify or diminish the effects of medications. It's advisable to provide patients with clear guidance on what to avoid:

• Grapefruit juice can increase the levels of Avanafil and Dapoxetine, leading to heightened side effects.
• Fatty meals may slow down the absorption of these medications.
• Alcohol can cause adverse reactions with Dapoxetine, exacerbating dizziness and drowsiness.

All these considerations point to the importance of patient education, an essential component of effective healthcare management. Regular follow-ups and consultations about possible interactions are indispensable for ensuring optimal safety and efficacy.

Table of Delivery Options