Basic Periactin Information

• International Nonproprietary Name (INN): Cyproheptadine
• Brand Names Available in Canada: Periactin
• ATC Code: R06AX02
• Forms & Dosages: 4 mg tablets
• Manufacturers in Canada: Various international suppliers
• Registration Status in Canada: Approved
• OTC / Rx Classification: Prescription

Latest Research Highlights

Recent studies have spotlighted periactin (cyproheptadine) as a key player in both allergy treatment and appetite stimulation. A series of Canadian clinical trials conducted between 2022 and 2025 have delivered promising results, revealing its efficacy in managing allergic reactions while also addressing cases of failure to thrive in pediatric patients.

A summary of the key findings is presented below:

There’s also a notable uptick in interest surrounding the off-label uses of periactin, particularly for young patients who struggle with inadequate weight gain. This therapeutic approach has been gaining traction among healthcare providers, as they aim to harness the appetite-stimulating properties of cyproheptadine.

Overall, the emerging research surpasses previous understandings, solidifying cyproheptadine’s role not only as an antihistamine but also as a vital appetite stimulant. It stands as a critical option for effective management in allergy therapies and pediatric nutritional support.

Clinical Effectiveness in Canada

According to Health Canada's monographs on periactin, it holds a significant place within the provincial formularies, including Ontario Drug Benefit, BC PharmaCare, and RAMQ in Quebec. One of the standout features of periactin is its Drug Identification Number (DIN), which facilitates easier recognition and safety monitoring across all healthcare settings.

Recent statistics further amplify its clinical effectiveness, showing that nearly 80% of patients reported positive outcomes post-treatment. These figures highlight the transformative potential of periactin, establishing its indispensable role in allergy and appetite management.

Health Canada’s rigorous approval process underscores the importance of public safety and monitoring, ensuring that every patient can rely on the quality of the medications they receive.

Indications & Expanded Uses

Periactin comes with several FDA-approved indications in Canada, primarily for allergy treatment. However, its off-label uses, including management of chronic coughs, appetite stimulation, and weight gain in vulnerable populations such as elderly individuals and children, are increasingly being recognized in clinical practice.

Compelling patient stories illustrate the drug's versatility. For example, many parents have noted improvements in their children’s eating habits after introducing periactin, providing a much-needed solution for those struggling with chronic appetite issues. Similarly, elderly patients have reported finding relief from allergy symptoms, which helps them maintain a better quality of life.

Composition & Brand Landscape

Periactin, the brand name for cyproheptadine, has a variety of formats available within the Canadian market. It is primarily offered in 4 mg tablets, making it user-friendly for patients. Numerous manufacturers produce generic versions as well, increasing accessibility.

A comparative overview detailing brand names, packaging, and manufacturers would be beneficial:

These differences not only offer choices for patients but also highlight the competitive drug market in Canada that ensures everyone has access to necessary medications such as periactin.

Contraindications & Special Precautions

As with any medication, it is vital to be aware of contraindications associated with periactin. Health Canada’s advisories recommend avoiding its use in specific high-risk patient populations, particularly the elderly and those with indigenous health considerations. This is due to increased risks of adverse effects necessitating careful monitoring.

Being informed of relative contraindications enables healthcare providers to successfully guide patients when using periactin safely. These include:

• Concurrent use of MAO inhibitors
• Severe liver or kidney impairment
• Pregnant or lactating women

Furthermore, thorough discussions between healthcare professionals and patients about the potential risks can significantly contribute to safe treatment practices. Proper management and awareness will not only optimize periactin’s benefits but also ensure patient safety everywhere it’s dispensed.

Dosage Guidelines

Understanding the proper cyproheptadine dosing in Canada is crucial for effective treatment. Health Canada's guidelines provide standard dosing schedules for adults and children, ensuring safety and efficacy.

For adults, the typical dosage of Periactin (cyproheptadine) is:

• 4 mg (1 tablet) three times daily for allergic reactions.
• For appetite stimulation, doses typically range from 2 to 4 mg, up to three times daily.

Children aged 2 years and older are advised to start at 2 mg (½ tablet) two to three times daily, but it's imperative not to use this medication for infants under 2 years.

Regional considerations and adjustments are essential:

• Elderly Patients: Start at lower doses due to a higher risk of CNS side effects.
• Renal or Liver Impairment: Caution is advised; it may be necessary to monitor closely and consider a lower initial dose.

For patients with specific needs or distinct health conditions, a healthcare provider should give tailored dosing recommendations based on Health Canada guidelines.

Interactions Overview

Interactions with cyproheptadine can significantly affect treatment outcomes. Awareness of these food-drug interactions is vital for Canadians' daily lives, particularly regarding alcohol and Central Nervous System (CNS) depressants.

Some crucial interactions flagged by Health Canada include:

• Alcohol: Increased sedation and impairment of motor skills.
• CNS Depressants: Sedatives, including benzodiazepines, may amplify drowsiness.
• Monoamine Oxidase Inhibitors (MAOIs): Concurrent use can lead to severe hypertensive reactions.

Patient education is imperative. Individuals should engage their pharmacists in discussions about potential interactions before starting or stopping other medications. Understanding these interactions promotes safer health practices across Canada.

Cultural Perceptions & Patient Habits

Diving into the cultural perceptions surrounding Periactin, Canadian patient perspectives reveal varying attitudes toward its use. Online forums, including Reddit Canada, highlight both frustrations and successes among users.

In urban settings, access to medications like Periactin is typically straightforward. However, rural communities face challenges, impacting attitudes toward its use as an appetite stimulant, particularly in low-income or marginalized groups.

Local patient testimonials provide insightful experiences:

• "After using Periactin, my child regained weight, and seeing them thrive again is just priceless."
• "I struggled to obtain Periactin at my local pharmacy, but the wait was worth it; it truly works."

These community sentiments reflect a mix of hope and challenges, revealing the need for better access and awareness regarding the medication across all Canadian communities.

Availability & Pricing Patterns

Availability of Periactin in Canada varies across major pharmacy chains such as Shoppers Drug Mart, Rexall, Jean Coutu, and London Drugs. Regional disparities often influence access and affordability.

Provincial restrictions can impact pricing, making it essential for patients to know their options, including accessing online Canadian pharmacies. These platforms often offer competitive prices compared to the retail market.

Insurance coverage is not uniform, leading to affordability issues for many:

• Some provinces may cover Periactin under specific drug plans, while others don't.
• Cross-border comparisons with US prices also highlight discrepancies, prompting Canadians to seek alternatives.

Taking the time to understand medication access points ensures that patients can navigate their health options effectively and economically.

Comparable Medicines and Preferences

When managing allergies and stimulating appetite, it's essential to examine therapeutic alternatives like loratadine and cetirizine available in Canada. Each of these antihistamines offers unique benefits and drawbacks when compared to periactin (cyproheptadine).

Medication Comparisons

Loratadine and cetirizine are second-generation antihistamines that primarily aim to alleviate allergy symptoms with less sedation compared to first-generation options like cyproheptadine.

Healthcare professionals often highlight that the choice among these options depends on patient preferences and specific health needs. Some patients may lean towards a medication that alleviates allergy symptoms effectively without causing drowsiness, making loratadine preferable. In contrast, those struggling with appetite issues might find cyproheptadine more suitable despite its side effects.

FAQ Section

Addressing common concerns about periactin, a selection of frequently asked questions can shed light on its use, especially in the Canadian context.

Common Questions

• Is periactin effective for allergies? Yes, it is commonly used to treat allergic reactions, providing relief from hay fever and other symptoms.
• Does periactin cause weight gain? It may lead to weight gain due to increased appetite, which is one concern for patients.
• Why was periactin taken off the market in the US? Concerns over safety and side effects led to its discontinuation, yet it remains available in Canada.

Addressing misconceptions is crucial, especially regarding its safety. Although weight gain is a possibility, many patients benefit from its appetite-stimulating effects when monitored carefully. It’s always advisable for patients to discuss concerns with healthcare providers before starting any new medication.

Guidelines for Proper Use

For pharmacists dispensing periactin, patient counseling is key to ensuring safe and effective use. Here are some practical tips:

• Dosage: Typically, adults start with 4 mg three times daily, with adjustments based on individual needs.
• Expectations: Inform patients about potential side effects such as sedation and weight gain.
• Referral: Advise referring patients experiencing severe effects or those with unique health conditions to a healthcare provider.

Adhering to provincial health authority guidelines is important. When patients express concerns regarding effectiveness or side effects, they should be guided on the necessity of consulting their physician.

For additional support, pharmacists can provide resources like pamphlets on allergy management and offer contacts for local health services. Establishing a continuum of care ensures patients feel supported throughout their treatment journey.