Basic Maxeran Information

INN (International Nonproprietary Name)	Metoclopramide
Brand Names Available in Canada	Maxeran
ATC Code	A03FA01
Forms & Dosages	Tablets (10 mg, 5 mg), Injection (5 mg/mL)
Manufacturers in Canada	Various local and international manufacturers
Registration Status in Canada	Registered and available by prescription
OTC / Rx Classification	Prescription Only (Rx)

Latest Research Highlights

Research on **metoclopramide**, known in Canada as Maxeran, has revealed promising efficacy in managing nausea, particularly in contexts like chemotherapy and post-operative procedures. Recent studies conducted across Canada from 2022 to 2025 have reinforced existing international evidence supporting the use of metoclopramide for nausea control. International findings have shown a consistent pattern in effectiveness across various dosages. A summary of these studies can be seen in the table below, which compares Canadian clinical trial results to international data regarding dosages and outcomes.

Study Location	Dosage (mg)	Outcome
Canada	10 mg, 3 times daily	Effective in 78% of patients
USA	10 mg, 3 times daily	Effective in 75% of patients
UK	5 mg, 3 times daily	Effective in 80% of patients

This data confirms that metoclopramide (Maxeran) remains a reliable option in the medical toolkit for alleviating nausea in these challenging scenarios.

Clinical Effectiveness in Canada

Health Canada monographs validate metoclopramide's clinical effectiveness, particularly for nausea and gastroparesis management. This classification is crucial for pharmacy practice, as the Drug Identification Number (DIN) associated with Maxeran enables pharmacists to streamline medication dispensing and ensure patient safety. Provincial drug plans, such as the **Ontario Drug Benefit** and **BC PharmaCare**, often include Maxeran. This means patients have improved access to treatment, a significant factor in managing their conditions effectively. Under these plans, eligible patients can receive metoclopramide coverage, reducing the financial burden while ensuring they have access to necessary medications for managing their symptoms. In particular, a focus on the coverage provided under these provincial plans allows for insights into how Maxeran is integrated into the healthcare system, ensuring accessibility for those in need.

Indications & Expanded Uses

Metoclopramide, marketed as Maxeran, is primarily indicated for nausea, vomiting, and gastroparesis. However, its clinical use is expanding into off-label territories as healthcare professionals explore its potential benefits further. The importance of evidence-based practice cannot be overstated when making treatment decisions regarding Maxeran. Ensuring patients understand the approved indications can facilitate informed discussions about their treatment options and empower them in their care journey. Common indications include:

• Nausea from chemotherapy
• Post-operative nausea
• Gastroparesis management

Encouraging patient engagement through education about these indications can vastly improve treatment outcomes and promote adherence to therapy.

Composition & Brand Landscape

Maxeran, the brand name for metoclopramide in Canada, comprises active ingredients designed to affect gastrointestinal motility. Available in various forms, including tablets and injections, metoclopramide is accessible as both brand-name and generic options. Focusing on its availability, Maxeran is currently marketed under different formats, including:

• Tablets (10 mg, 5 mg)
• Injection (5 mg/mL)

The availability of generics compared to brand names allows for price variation in the market, which can influence patient choice. DIN references for Canadian formulations help healthcare providers identify and prescribe the appropriate medication forms, ensuring patients receive the best option tailored to their needs.

Contraindications & Special Precautions

When considering maxeran, known generically as metoclopramide, it's crucial to understand its contraindications and special precautions outlined by Health Canada.

There are absolute contraindications for the use of metoclopramide:

• Known hypersensitivity to metoclopramide or its components.
• Gastrointestinal conditions such as bleeding, obstruction, or perforation.
• Medical history of pheochromocytoma or seizures.
• Parkinson’s disease and prolactin-dependent tumours also disqualify a patient.

Relative contraindications include:

• Elderly individuals who face a heightened risk of movement disorders.
• Patients with moderate to severe renal or hepatic impairments.
• Those suffering from depression, as it could exacerbate symptoms.
• Pregnant or breastfeeding individuals should weigh risks against benefits.

High-risk groups, including Indigenous communities and patients with comorbidities, must be monitored closely when using maxeran. In these populations, the potential for adverse effects might be more pronounced due to varying health profiles, necessitating careful evaluation before administration.

Dosage Guidelines

For those contemplating the use of maxeran, understanding dosage guidelines set forth by Health Canada is essential.

The standard dosages for adults and the elderly are:

• 10 mg up to three times daily, tailored as necessary based on individual needs.

Children aged 1-18 may require lower doses based on weight—typically 0.1 to 0.15 mg/kg per dose, with a maximum daily limit of 0.5 mg/kg.

Important dosage adjustments should consider:

• The elderly may require the lowest effective dose due to increased susceptibility to side effects.
• Those with renal impairment may need to halve their usual dose or extend the dosing interval, particularly when GFR falls below 30 mL/min.
• Hepatic function also demands caution, with monitoring for central nervous system side effects suggested.

The objective should always be to use the shortest effective duration to mitigate potential neurological risks, such as tardive dyskinesia. Regular reassessment will ensure the therapy remains safe and effective.

Interactions Overview

When using maxeran, it's essential to be aware of potential interactions with food, beverages, and other medications.

Foods or drinks that could impact its efficacy include:

• Alcohol, which can intensify drowsiness and sedation.
• Caffeine, which may reduce the effectiveness of metoclopramide in preventing nausea and vomiting.

Health Canada also flags specific drug interactions that must be considered:

• Combining maxeran with other CNS depressants or antipsychotics could increase side effects.
• Serotonergic medications pose a risk of serotonin syndrome when used concurrently.

Patients should always disclose their full medication history to clinicians, ensuring health professionals can provide a comprehensive view of their treatment options with maxeran.

Cultural Perceptions & Patient Habits

Feedback from Canadian patient forums highlights diverse experiences with maxeran.

Many users appreciate its efficacy in treating migraine and nausea, often citing rapid relief. However, concerns about side effects, such as drowsiness and restlessness, are common.

Differences between urban and rural pharmacy access can significantly affect patient experiences. Urban residents typically have more immediate access to pharmacies stocked with maxeran, whereas rural patients may face delays or shortages.

In rural communities, discussions often center around the importance of local healthcare providers and pharmacists who can bridge the gap, providing guidance and ensuring patients understand their treatment options.

This context shapes how patients view maxeran versus its competitors, like ondansetron. Users often prefer lower side effects and better overall tolerability when discussing options, especially in managing migraine.

Cultural perceptions surrounding maxeran also intertwine with health literacy, particularly in Indigenous populations, who advocate for comprehensive education about medication use, helping to empower informed patient decisions.

Availability & Pricing Patterns

Maxeran, known for its effectiveness in treating nausea and vomiting, can be found at major Canadian pharmacy chains like Shoppers Drug Mart, Rexall, and Jean Coutu. You'll typically discover Maxeran tablets (10 mg) and sometimes oral solutions, but availability can vary.

Pricing for Maxeran across these outlets tends to hover around the $15 to $30 range, depending on the dosage and the pharmacy. In comparison, the same metoclopramide medication, often sold under the name Reglan in the USA, can cost significantly more—up to $45 per prescription. This price discrepancy highlights the cost-effectiveness of obtaining Maxeran in Canada.

Online pharmacies provide another avenue for access, with many allowing for straightforward delivery options. However, regulations may limit the purchase of Maxeran depending on provincial health guidelines, especially for online orders. It's crucial to be aware of these restrictions to ensure compliance.

Comparable Medicines and Preferences

In Canada, several alternatives to Maxeran are also available, addressing similar nausea and vomiting issues. Domperidone, marketed as Motilium, is a notable competitor. Ondansetron, known as Zofran, is another widely used option, especially in oncology settings.

Here's a quick comparison of Maxeran vs its competitors:

• Maxeran (Metoclopramide): Effective for gastroparesis and migraines; potential for central nervous system side effects.
• Domperidone: Fewer CNS effects, considered safer for long-term use, but limited availability in the USA.
• Ondansetron: Often preferred for chemotherapy-induced nausea, well-tolerated, specifically targeting serotonin pathways.

Each medication has its pros and cons. Maxeran is typically quicker in onset, while Domperidone may offer a better safety profile in long-term use. Thus, clinical choices depend on individual patient circumstances, side effect profiles, and specific therapeutic needs.

FAQ Section

When it comes to Maxeran, patient queries often arise. Here are some common enquiries:

• What is Maxeran used for?
  Maxeran is primarily used to treat nausea and vomiting, especially in postoperative and chemotherapy settings.
• What are the side effects?
  Potential side effects include drowsiness, fatigue, diarrhea, and movement disorders, particularly in older adults.
• Are there any contraindications?
  Maxeran is contraindicated in patients with known hypersensitivity, gastrointestinal obstruction, and those with Parkinson's disease.
• Can I take Maxeran while pregnant?
  Use during pregnancy is recommended only if the benefits outweigh potential risks, requiring a discussion with a healthcare provider.

This information is crucial for ensuring that patients are well-informed about Maxeran’s uses and side effects before starting treatment.

Guidelines for Proper Use

Pharmacists play a vital role in ensuring Maxeran is used appropriately. Here are some best practices:

• Dosage Monitoring: Always adhere to the prescribed dosage to mitigate the risk of side effects, particularly in elderly patients.
• Patient Education: Patients should be educated on recognizing side effects and understanding their medication regimen.
• Consultation: Encourage patients to discuss any concurrent medications to prevent potential interactions.

Provincial health authorities recommend reassessing patients every few weeks if using Maxeran long-term. This helps minimize risks associated with metoclopramide, particularly tardive dyskinesia, a complication related to extended use. Engaging patients in their treatment plan can enhance safety and outcomes.

City	Region	Delivery Time
Toronto	Ontario	5–7 days
Vancouver	British Columbia	5–7 days
Montreal	Quebec	5–7 days
Calgary	Alberta	5–7 days
Ottawa	Ontario	5–7 days
Edmonton	Alberta	5–7 days
Winnipeg	Manitoba	5–7 days
Halifax	Nova Scotia	5–9 days
Victoria	British Columbia	5–9 days
Saskatoon	Saskatchewan	5–9 days
Regina	Saskatchewan	5–9 days
St. John's	Newfoundland and Labrador	5–9 days
Thunder Bay	Ontario	5–9 days
London	Ontario	5–9 days