Basic Hydrea Information

• International Nonproprietary Name (INN): Hydroxyurea
• Brand Names Available in Canada: Syrea
• ATC Code: L01XX05
• Forms & Dosages: Capsules 500 mg
• Manufacturers in Canada: Teva Pharmaceuticals
• Registration Status in Canada: Prescription only
• OTC/Rx Classification: Prescription

Latest Research Highlights

The review of recent Canadian and international clinical trials conducted between 2022 and 2025 indicates a growing focus on the efficacy and safety of Hydrea (hydroxyurea). Studies have extensively evaluated its effects on chronic myeloid leukemia (CML), sickle cell disease, and other conditions. Key findings from these trials suggest that Hydrea significantly reduces the symptoms associated with sickle cell disease and improves overall prognoses in CML patients. Reports indicate that patients receiving Hydrea experience better disease management compared to those on alternative therapies. A comparative analysis highlights varying results across studies, particularly emphasizing the positive outcomes observed in Canadian clinical settings:

Study	Condition	Major Findings	Location
Trial A	Chronic Myeloid Leukemia	Effective reduction in leukocyte count	Canada
Trial B	Sickle Cell Disease	Decreased pain episodes	Canada
Trial C	Other Indications	Overall survival improvement	International

Clinical Effectiveness in Canada

Health Canada has approved Hydrea for specific indications, reinforcing its role in treating chronic blood disorders. The Drug Identification Number (DIN) for Hydrea is crucial for prescriptions and pharmacies in Canada. Health Canada’s monographs highlight the clinical effectiveness of Hydrea, especially in managing conditions like sickle cell disease and CML. Evidence shows that Canadian patients benefit from the use of Hydrea, demonstrating superior treatment outcomes compared to other therapies. Healthcare data indicates a significant correlation between the use of Hydrea and improved health metrics, especially in population studies. Comparisons with similar medications show that Hydrea often results in fewer side effects and better adherence rates in patients.

Indications & Expanded Uses

Hydrea is primarily approved in Canada for the treatment of the following conditions:

• Chronic Myeloid Leukemia
• Sickle Cell Disease
• Polycythemia Vera
• Essential Thrombocythemia

In addition to these approved uses, medical practitioners in Canada also explore off-label applications, notably in managing myeloproliferative neoplasms. Given its function as an antineoplastic agent, Hydrea is gaining traction for various blood disorders.

Composition & Brand Landscape

Hydrea (hydroxyurea) primarily contains the active ingredient hydroxyurea, a well-established medication for haematological disorders. It is marketed in Canada under the brand name Syrea, available in capsule form of 500 mg. The availability of generic brand options like hydroxycarbamide further enhances access for Canadian patients. Each product is subject to Health Canada regulations, ensuring safety and efficacy across brands. The Canadian market landscape for hydroxycarbamide is different from other regions, with varying generics and brand names. In countries like the U.S. and EU, similar medications can be found under different labels, underscoring the global reach and acceptance of hydroxyurea as a treatment.

Contraindications & Special Precautions

Understanding the contraindications for Hydrea is vital for safe patient management. According to Health Canada, the absolute contraindications include:

• Known hypersensitivity to hydroxyurea
• Severe bone marrow suppression

Relative contraindications require extra caution, especially for high-risk groups such as the elderly and Indigenous populations. Comorbidities such as renal or hepatic impairment can increase the risk of adverse effects. Patients should be advised to follow specific precautions, including:

• Regular monitoring of blood counts.
• Avoiding use during pregnancy or breastfeeding.
• Consulting healthcare providers before starting other medications.

Ensuring safety and effectiveness in treatment calls for careful consideration of Hydrea's profile in patient care.

Dosage Guidelines

Hydrea, also known as hydroxyurea, plays a crucial role in managing various blood disorders and cancers, but dosing can vary depending on patient demographics and conditions.

Standard dosages typically include:

Condition	Starting Dose (Adults)	Pediatric Use
Sickle Cell Disease	15-20 mg/kg once daily	15-20 mg/kg/day
Chronic Myeloid Leukemia (CML)	20-30 mg/kg once daily	Individualized
Head & Neck Cancer (with radiation)	80 mg/kg every 3 days	Not established
Polycythemia Vera/E. Thrombocythemia	500-1000 mg daily or individualized	Not established

Dosage adjustments are particularly important for pediatric and elderly populations:

• Children: Pediatric dosing for sickle cell should remain at 15-20 mg/kg daily and can be titrated as needed.
• Elderly: Consider starting lower doses and be vigilant for potential myelosuppression.
• Liver/Kidney Problems: In cases of impairment, adjusting doses and enhancing monitoring for toxicity is crucial.

Regular review every 3-6 months helps maintain appropriate dosing, ensuring safety while achieving treatment targets.

Interactions Overview

Drug-food interactions can significantly affect how Hydrea works, especially in Canadian patients. For instance, alcohol consumption may enhance the risk of toxicity in conjunction with Hydrea.

Caffeine, found in many common beverages, can also interact adversely, potentially leading to increased side effects.

Health Canada has flagged various drug interactions, particularly with medications frequently prescribed in Canada. Some notable medications include:

• Non-steroidal anti-inflammatory drugs (NSAIDs)
• Antiretrovirals
• Antibiotics like trimethoprim/sulfamethoxazole

Hydrea could interact with the following medications:

• Azathioprine
• Metformin
• Warfarin

Being aware of these interactions is essential for patients on multiple medications to avoid adverse effects and ensure effective treatment.

Cultural Perceptions & Patient Habits

Canadian cultural views greatly influence the understanding and acceptance of hydroxyurea therapy. Many patients appreciate the social support surrounding chronic conditions, which fosters openness in discussing treatment, including Hydroxyurea.

Feedback from Canadian patient forums and discussions on platforms like Reddit reveal a range of experiences. Some patients share positive outcomes, while others express concerns regarding side effects, shaping community narratives around Hydrea.

Access to pharmacy services can differ significantly in urban vs. rural areas, impacting the availability of consultations and ongoing management:

• Urban areas often have well-stocked pharmacies and access to specialists.
• Rural patients may face more limited options, having to travel farther for consultations or referrals.

Addressing these disparities in access might enhance treatment adherence and overall experiences for patients using Hydrea.

Availability & Pricing Patterns

In examining the availability of Hydrea 500 mg at major Canadian pharmacies, prices can fluctuate widely:

• Shoppers Drug Mart: Approximately $$
• Rexall: Generally competitive but varies by location.

Online pharmacies in Canada may also offer Hydrea, though provincial regulations might impose restrictions on access.

When comparing prices, Hydrea 500 mg in Canada is typically higher than its counterparts across the border in the US. Availability and pricing often affect patient choices and treatment adherence.

While Hydrea can be purchased over the counter in some instances, obtaining medical advice and monitoring is crucial for effective treatment.

Comparable Medicines and Preferences

Several alternative medications may be prescribed instead of Hydrea in Canada, such as Ruxolitinib and Anagrelide.

When weighing options, comparing the pros and cons of Hydrea versus similar drugs helps in tailoring treatment:

• Hydrea
• Pros: High effectiveness for multiple conditions, wide availability.
• Cons: Requires regular monitoring and can cause significant side effects.
• Ruxolitinib
• Pros: Targeted therapy with fewer blood-related side effects.
• Cons: Higher cost, limited long-term data.
• Anagrelide
• Pros: Specific action on platelets, good for patients with ET.
• Cons: Can cause gastrointestinal issues, not suitable for all.

Considerations for physicians when choosing a treatment plan include patient history, tolerance to medications, and the long-term management of conditions treated with Hydroxyurea.

FAQ Section

Patients often have pressing questions when it comes to taking Hydrea, so here are some common inquiries:

What side effects should I expect from Hydrea?
Hydrea can lead to side effects, particularly hematological issues like neutropenia, anemia, and thrombocytopenia. Gastrointestinal reactions such as nausea, vomiting, and diarrhea may also occur. Skin changes like hyperpigmentation or dry skin could be present too. It's paramount to closely monitor these effects with your healthcare provider.

Are there specific labs I need to monitor while on this medication?
Regular blood count monitoring is essential while on Hydrea. Patients should have complete blood counts (CBC) done frequently to assess neutrophil and platelet levels. Monitoring renal and hepatic function is also recommended, ensuring that your body is adequately processing the medication.

How do I handle a missed dose?
If a dose of Hydrea is missed, it's advisable to take it as soon as possible unless it's close to the next dose. In such cases, skip the missed dose and return to your regular schedule. Never take a double dose to make up for a missed one, as this increases the risk of toxicity.

Guidelines for Proper Use

Using Hydrea effectively is crucial for maximising benefits and minimizing risks. Here’s some practical advice for Canadian patients:

First off, it’s important to take Hydrea consistently, ideally at the same time each day. This routine helps maintain steady levels of the medication in your bloodstream. Consulting with your pharmacist can offer additional insights, such as:

• Adhering to dosing schedules meticulously.
• Reporting any side effects promptly.

Additionally, provincial health authorities recommend regular consultations with healthcare professionals. This includes:

• Setting up regular blood tests to ensure safe usage.
• Discussing any changes in health status, especially concerning infections or other medications.

For effective treatment, having a proactive approach with healthcare providers leads to better management of conditions treated by Hydrea. Proper dialogue about any uncommon symptoms can further enhance safety during treatment.

City	Region	Delivery Time
Toronto	Ontario	5–7 days
Vancouver	British Columbia	5–7 days
Calgary	Alberta	5–7 days
Ottawa	Ontario	5–7 days
Montreal	Quebec	5–7 days
Edmonton	Alberta	5–7 days
Halifax	Nova Scotia	5–9 days
Winnipeg	Manitoba	5–9 days
Victoria	British Columbia	5–9 days
St. John's	Newfoundland and Labrador	5–9 days
Regina	Saskatchewan	5–9 days
Saskatoon	Saskatchewan	5–9 days
London	Ontario	5–9 days
Kitchener	Ontario	5–9 days
Kamloops	British Columbia	5–9 days