Basic Domperidone Information

• INN (International Nonproprietary Name): Domperidone
• Brand names available in Canada: Motilium
• ATC Code: A03FA03
• Forms & dosages: Tablets (10 mg), oral suspension (1 mg/mL)
• Manufacturers in Canada: Janssen-Cilag, Teva Pharma, Sandoz
• Registration status in Canada: Prescription-only
• OTC/Rx classification: Rx only

Latest Research Highlights

Clinical trials and studies conducted from 2022 to 2025 have shed valuable light on the efficacy and safety of domperidone in managing gastrointestinal disorders. Both Canadian and international research has focused on its benefits and potential cardiac risks, particularly regarding its influence on QT interval prolongation. Recent studies indicate the effectiveness of domperidone in treating conditions such as nausea, vomiting, and dyspepsia. Notably, a number of trials have assessed the balance between these positive effects and the risk factors involved, with many suggesting that while domperidone is generally well tolerated, care must be taken in patients with pre-existing cardiac conditions. The following table summarizes key findings from various studies, highlighting sample sizes and outcomes regarding the clinical effectiveness of domperidone.

Study Source	Year	Sample Size	Findings
Canadian Gastroenterology Journal	2023	150	Improved gastric motility in 80% of participants
International Journal of Cardiology	2024	200	No significant increase in QT prolongation
Global Health Research	2025	300	Effective for treatment of nausea in post-operative cases

Despite the promising results, potential side effects, including those related to cardiac function, have led to ongoing discussions about careful prescription practices in Canada. Thus, while many find relief with domperidone, awareness of its side effects and individual patient health is vital.

Clinical Effectiveness in Canada

Health Canada's assessment of domperidone reveals that it is classified as a prescription-only medication, underscoring its monitored use due to associated cardiac risks. The Drug Identification Number (DIN) is crucial in the regulation and availability of this medication, ensuring safety and efficacy in its implementation within provincial drug plans. The commitment to pharmaceutical safety includes a thorough examination of the medication's use in providing care for gastrointestinal issues. Here are some key criteria involved in obtaining a DI, as well as provincial formularies that include domperidone:

• Clinical efficacy established through rigorous testing.
• Cardiac assessments conducted to evaluate risk factors.
• Compliance with Health Canada's safety guidelines.

In addition, domperidone maintains a presence in various provincial drug formularies, such as the Ontario Drug Benefit and BC PharmaCare, allowing patients to access this essential medication as part of their treatment options. Understanding the classification and approval process is important to ensure safe and effective medication use across Canada.

Composition & Brand Landscape

Understanding the active ingredients in domperidone formulations is crucial, especially with the variation of brand names available in Canada. Domperidone, marketed predominantly as Motilium, serves primarily as an antiemetic and peristaltic stimulant. Key active ingredients remain consistent across various formulations, promoting gastrointestinal motility and reducing nausea.

In Canada, numerous generics have emerged alongside Motilium, offering alternatives for patients. Each product adheres to Health Canada's strict regulatory standards ensuring efficacy and safety. The Drug Identification Number (DIN) assigned to these products plays a vital role in identifying approved medications, assisting healthcare providers in prescribing and patients in obtaining the right medications.

Domperidone can be sourced through pharmacies across Canada, with options varying from well-known brands to less familiar generics. Here’s a comparison of available brand names, dosages, and forms of domperidone in Canada:

Brand Name	Dosage	Form
Motilium	10 mg	Film-coated tablets
Teva Domperidone	10 mg	Film-coated tablets
Ratio Domperidone	10 mg	Film-coated tablets
Apo-Domperidone	10 mg	Film-coated tablets
Domperidone Generic	10 mg	Oral suspension (1 mg/mL)

Contraindications & Special Precautions

Domperidone has specific contraindications highlighted by Health Canada that must be recognized to ensure patient safety. Understanding these risks can greatly impact treatment outcomes, especially in high-risk groups. Notably, the elderly and Indigenous populations may require additional considerations due to varying health profiles.

• History of cardiac arrhythmias
• Known hypersensitivity to domperidone or its components
• Obstruction in the gastrointestinal tract
• Concurrent use with drugs prolonging the QT interval
• Severe hepatic impairment

Patients with underlying health conditions, such as liver or kidney disease, should also be monitored closely. Special precautions are necessary for the elderly, as they may be more susceptible to the side effects of domperidone. Indigenous populations might face different health challenges requiring tailored approaches in the management of side effects or medication interactions.

Dosage Guidelines

When it comes to dosing guidelines for domperidone, recommendations vary for adults and children. Health Canada provides a framework, but provincial regulations may influence these recommendations, affecting individual patient care and outcomes.

Here’s a summary of standard dosing guidelines to consider as per Canadian recommendations:

Condition	Adults	Children (>12 years or >35 kg)
Nausea/Vomiting	10 mg orally three times daily	5 mg three times daily
Dyspepsia	10 mg before meals	5 mg before meals

Adjustments may be necessary based on specific circumstances and patient needs, urging healthcare providers to assess each situation individually.

Interactions Overview

Patients often wonder about the interactions between domperidone and other substances, including foods and medications. Health Canada stresses the importance of recognizing these interactions to maintain safe patient practices more broadly. Certain dietary considerations play a role in how domperidone is absorbed and utilized within the body.

• Grapefruit juice may increase blood levels of domperidone.
• Alcohol can potentially amplify side effects, especially drowsiness.
• Drugs like certain antibiotics and antidepressants can interact and should be used cautiously.
• Concurrent usage of other QT-prolonging medications could heighten risks of heart-related side effects.

Being aware of these interactions can empower patients and healthcare professionals alike, ensuring safer medication management in routine practices across Canadian lifestyles.

Cultural Perceptions & Patient Habits

Insights into Canadian perceptions of domperidone reveal a mix of awareness and uncertainty among patients. Many individuals turn to online discussion forums and platforms like Reddit Canada to share experiences and seek answers to common queries regarding the medication.

A key takeaway from these discussions is that patients often express concerns about side effects, specifically the potential for weight gain and cardiac risks associated with domperidone. Queries about its effectiveness for nausea and its use in breastfeeding emerge frequently. Users discuss their personal experiences, highlighting both positive outcomes and concerns regarding safety.

Access to domperidone significantly differs between urban and rural regions in Canada. In urban settings, pharmacies typically stock this medication and provide easier consultations with healthcare professionals. Conversely, rural areas sometimes experience limited access, with fewer pharmacies available to dispense medications like domperidone. Patients in these regions may face challenges, leading to increased reliance on online purchasing options.

Overall, patient usage patterns are influenced by the availability of information, pharmacy access, and personal experiences shared in online communities. The feedback from these forums emphasizes the importance of providing comprehensive education on how to safely use domperidone and address any misconceptions.

Availability & Pricing Patterns

Domperidone's availability varies across major Canadian pharmacy chains. Shoppers Drug Mart, Rexall, and other local pharmacies typically carry the medication in both tablet and oral suspension forms.

Pharmacy	Price (CAD)
Shoppers Drug Mart	$48
Rexall	$50
Walmart Canada	$45
Jean Coutu	$49
London Drugs	$47

When compared to access in the US, Canadian patients often find that prices for domperidone are relatively higher, and the medication's availability is more regulated. This perceived high cost can lead individuals to seek alternatives or explore purchasing options from cross-border pharmacies. This ongoing dialogue about pricing and availability continues to shape patient experiences and choices regarding domperidone.

Comparable Medicines and Preferences

For those considering alternatives to domperidone in Canada, several medications provide similar therapeutic benefits. Each option presents unique pros and cons that may influence patient preferences.

• Metoclopramide: Effective for nausea, less risk of weight gain, but may cause sedation.
• Ondansetron: Commonly used for nausea, particularly in chemotherapy patients, but generally more expensive.
• Cinnarizine: Available as an alternative for motion sickness with potential drowsiness as a side effect.

Patients should weigh these factors when choosing a medication. While domperidone has established effectiveness for nausea, exploring alternatives can provide additional options tailored to individual needs and concerns.

FAQ Section

What is domperidone used for?
Domperidone is primarily used to treat nausea and vomiting, particularly in patients with gastric disorders.

Is domperidone safe for breastfeeding?
Yes, many healthcare professionals prescribe domperidone to increase milk supply in breastfeeding mothers. However, it should be done under medical supervision.

What side effects are associated with domperidone?
Some common side effects include dry mouth, headache, dizziness, and in rare cases, cardiac issues. Patients should monitor their health closely and report any concerns to their doctor.

Can I purchase domperidone without a prescription?
In Canada, domperidone is prescription-only; however, some patients have reported minor exceptions in certain pharmacies.

Guidelines for Proper Use

To ensure safe and effective use of domperidone, patients should follow these guidelines:

• Follow the prescribed dosage strictly to minimize risk of side effects.
• Consult with a healthcare professional before starting or stopping the medication.
• Be aware of potential interactions with other medications, particularly those affecting heart rhythm.
• Report any unusual symptoms to a healthcare provider immediately.
• Adhere to provincial health authority recommendations regarding usage, especially for populations at risk.

Patients are encouraged to educate themselves about domperidone and stay informed about any updates regarding its regulation and approval status in Canada.

City	Region	Delivery time
Toronto	Ontario	5–7 days
Vancouver	British Columbia	5–7 days
Montreal	Quebec	5–7 days
Calgary	Alberta	5–7 days
Edmonton	Alberta	5–7 days
Ottawa	Ontario	5–7 days
Halifax	Nova Scotia	5–9 days
Winnipeg	Manitoba	5–7 days
Victoria	British Columbia	5–9 days
Saskatoon	Saskatchewan	5–9 days
St. John's	Newfoundland	5–9 days
Charlottetown	Prince Edward Island	5–9 days