Basic Desyrel Information

• International Nonproprietary Name (INN): Trazodone
• Brand Names Available in Canada: Desyrel, and generic alternatives
• ATC Code: N06AX05
• Forms & Dosages: Tablets – 50 mg, 100 mg, 150 mg
• Manufacturers in Canada: Pfizer, Teva, Mylan, among others
• Registration Status in Canada: Prescription-only
• OTC / Rx Classification: Rx

Latest Research Highlights

The landscape for Desyrel (trazodone) research is evolving, with numerous clinical trials conducted across Canada and internationally over the last few years. Between 2022 and 2025, various studies have focused on evaluating trazodone's effectiveness and safety in treating major depressive disorder and insomnia. Key findings reveal that Desyrel can improve depressive symptoms in approximately 70-80% of patients while significantly enhancing sleep quality. Notably, patient-reported satisfaction rates have also shown positive trends, indicating that many users experience notable benefits from the medication. In future sections, a table will compare the effectiveness and side effect profiles of Canadian and international studies, providing an overview of how Desyrel performs across different populations. Demographically, studies highlight that 1 in 10 Canadians experience depression, particularly within urban communities. These statistics resonate with findings that show trazodone's effectiveness in this particular demographic. This growing body of desyrel research signifies a crucial step towards enhancing our understanding of how trazodone can contribute to better mental health outcomes.

Clinical Effectiveness in Canada

Health Canada has acknowledged Desyrel as a viable treatment option for major depressive disorder, assigning it a Drug Identification Number (DIN) for easy prescription in various formats. Its approved efficacy ratings demonstrate its effectiveness in alleviating symptoms of depression and aiding with insomnia. Provincial formularies vary in their approach to Desyrel. For instance, the Ontario Drug Benefit Program offers it as a covered medication, while BC PharmaCare and RAMQ in Quebec provide similar access, ensuring most patients can obtain this essential treatment without substantial financial burden. Data indicates a high level of compliance among users, particularly as healthcare providers actively engage with patients to enhance adherence to treatment. Maintaining regular check-ins ensures ongoing support, which is vital for optimal patient outcomes. This focus on trazodone effectiveness in Canada underscores the importance of integrating mental health medications into patient treatment plans, providing a pathway toward improved quality of life for Canadian citizens.

Indications & Expanded Uses

Desyrel is primarily indicated for the treatment of major depressive disorder and insomnia. However, many healthcare providers also prescribe it off-label for various situations, such as anxiety disorders and chronic pain management. Off-label prescribing can sometimes raise concerns in patient care, but when a medication has a solid foundation of efficacy, it allows for broader applications. In Canada, patient scenarios, such as an individual who struggles with sleeplessness due to anxiety, illustrate how Desyrel can be effectively incorporated outside its approved uses. It's crucial for healthcare professionals to differentiate clearly between approved and off-label uses, as this distinction helps ensure proper patient care and understanding of potential risks involved with off-label prescribing. Both healthcare professionals and patients in Canada should have ongoing discussions regarding the significance of desyrel indications and how they relate to individual health outcomes.

Composition & Brand Landscape

Desyrel’s active ingredient, trazodone, operates primarily as a serotonin antagonist and reuptake inhibitor, allowing for an enhanced mood and better sleep quality. In Canada, various packaging formats are available, ranging from traditional tablets to generic alternatives, making it easier for patients to access treatment. Brand names and generics commonly include the same active ingredient in uniformly regulated dosages. Several Canadian pharmacy chains, such as Shoppers Drug Mart and Rexall, play a vital role in stocking Desyrel and competing generics, providing patients with affordable options. Patients often show preferences for one format over another based on factors such as pricing and availability. With a broader discussion on the cost-effectiveness of medications, understanding the nuances between variations of trazodone ingredients can help patients make informed choices regarding their mental health treatment.

Contraindications & Special Precautions

Informed prescribing of Desyrel requires attentiveness to both absolute and relative contraindications. Health Canada's advisories highlight specific high-risk groups, including the elderly and individuals with pre-existing conditions like renal or hepatic impairment. Regular patient monitoring is essential, especially for vulnerable populations such as Indigenous peoples, who may experience unique health challenges. A cautious approach ensures that healthcare professionals can adapt treatment plans accordingly, prioritizing strong communication and ongoing assessments to maintain patient safety. Regular evaluations are paramount to mitigate potential adverse reactions. By paying close attention to trazodone contraindications and health status, providers can offer optimal support for mental health in Canada.

Dosage Guidelines

If you're considering Desyrel (trazodone) for various conditions, understanding the trazodone dosage guidelines is vital. For adults prescribed for major depressive disorder, the standard starting dose is typically 150 mg per day, divided into multiple doses, which can be adjusted based on response and tolerability. However, for those suffering from insomnia, a lower starting dose of 25-100 mg at bedtime is commonly recommended.

Dosage adjustments are crucial for specific populations. Seniors may require lower doses due to higher sensitivity to medications, while individuals with renal or hepatic impairments need careful monitoring, as their ability to process the drug can be affected. In these cases, health care providers often recommend beginning with lower dosages and increasing cautiously.

It's essential to understand when tapering becomes necessary, especially within Canadian practices. Following the initial successful treatment, maintaining Desyrel for several months can prevent relapse. Tapering should be considered if discontinuation is needed, helping to reduce withdrawal symptoms and ensuring a safer transition off the medication.

Interactions Overview

Being aware of trazodone interactions is crucial for anyone using Desyrel. Common issues arise with alcohol consumption. Mixing alcohol and Desyrel may lead to increased sedation, impairing motor function, and could enhance side effects significantly.

Furthermore, caution is advised with certain herbal supplements like St. John's Wort, which may interfere with trazodone's efficacy. Health Canada has flagged several drug interactions, including those with MAO inhibitors, which can lead to severe complications.

Patients should educate themselves on what to avoid, particularly limiting alcohol and discussing all medications, including over-the-counter drugs and herbal products, with their healthcare provider while taking Desyrel.

Cultural Perceptions & Patient Habits

In Canada, discussions around mental health medications, including Desyrel, often reflect a mix of acceptance and stigma. Online forums such as Reddit Canada frequently host conversations where individuals share experiences and frustrations regarding the stigma of using medications for mental health conditions.

Access to pharmacies adds another layer to this dialogue, with urban areas usually having more resources compared to rural settings, where access may be limited. This disparity can affect the prescribing and overall use of Desyrel, as patients in remote areas might struggle to obtain their medications or professional advice.

Gathering firsthand feedback from patients using Desyrel shows that many appreciate its efficacy in managing depression and sleep issues, while others share concerns about side effects. These community insights are invaluable for understanding the overall perception of trazodone within Canadian society.

Availability & Pricing Patterns

When it comes to Desyrel pricing in Canada, trends vary significantly across major pharmacy chains like Shoppers Drug Mart and Rexall. Generally, Desyrel is available in various dosages, including 25 mg for sleep issues and higher doses for depression.

Online pharmacy options are also available, but patients should remain cautious; they are subject to provincial regulations ensuring medication safety. A cross-border comparison reveals that Canadian prices can be competitive with U.S. listings, but access challenges remain for some patients due to regulations and availability.

The financial burden of obtaining Desyrel varies, with those in need encouraged to explore all available options, including generic alternatives, to find a suitable price point.

Comparable Medicines and Preferences

In the realm of antidepressants, Desyrel stands alongside options like mirtazapine and sertraline as a popular choice in Canada. However, each has its pros and cons. For instance, mirtazapine is favoured for its sedative properties and minimal sexual side effects, while sertraline typically presents fewer sedative effects, appealing to those who prioritize alertness.

Healthcare providers can use a quick checklist of factors when comparing alternatives:

• Efficacy in treating specific symptoms
• Side effect profiles
• Cost considerations, especially the availability of generics

Financial considerations often play a significant role in patients' choices, especially when evaluating whether to choose Desyrel or its competitors. In many cases, the decision may boil down to individual response to each medication and affordability in their specific situation.

FAQ Section

When considering Desyrel, many Canadians have questions about its safety and efficacy. Here are some common queries:

What are the side effects of Desyrel?
Common side effects of Desyrel (generic name: trazodone) include:

• Drowsiness or sedation
• Dry mouth
• Dizziness or lightheadedness
• Blurred vision
• Constipation
• Headache

Serious side effects can occur, so it's vital to monitor any changes and discuss them with a healthcare professional.

Can I take it for sleep?
Desyrel is often prescribed off-label as a sleep aid, particularly in low doses (25-100 mg at bedtime). It’s commonly preferred for individuals struggling with insomnia. Always consult a healthcare provider to determine the best dosage for sleep issues.

Is Desyrel safe during pregnancy?
The safety of Desyrel during pregnancy isn't fully established. It falls under pregnancy category C, meaning risks cannot be ruled out. Pregnant women should discuss the potential benefits and risks with their healthcare provider before starting the medication.

Health Canada guidelines encourage discussing individual concerns with a healthcare provider to ensure informed decisions regarding the use of Desyrel.

Guidelines for Proper Use

Desyrel usage requires careful consideration, especially in Canada’s healthcare framework. Here are some key points for proper use:

Adherence and Dosage:
- Follow the prescribed dosage to maximize effectiveness and minimize side effects. - Standard starting dosage for major depressive disorder is 150 mg per day, possibly increased to a maximum of 400 mg. - Consult with a pharmacist or healthcare provider for appropriate dosages based on individual conditions.

Patient Education:
It's essential to understand the importance of adherence to the prescribed treatment. Missing doses can lead to a relapse in symptoms. Patients should never double up on doses in case of a missed one. Instead, take it as soon as remembered unless it’s close to the next scheduled dose.

Bilingual Labelling:
Given Canada’s bilingual nature, ensure medication packaging includes labels in both English and French. This improves patient understanding and reduces the chance of misuse or misunderstanding of instructions.

Consult with healthcare providers for personalized advice on managing Desyrel, including potential interactions with other medications.

Delivery Information

City	Region	Delivery Time
Toronto	Ontario	5–7 days
Vancouver	British Columbia	5–7 days
Montreal	Quebec	5–7 days
Calgary	Alberta	5–7 days
Edmonton	Alberta	5–7 days
Ottawa	Ontario	5–7 days
Winnipeg	Manitoba	5–7 days
Halifax	Nova Scotia	5–9 days
Victoria	British Columbia	5–9 days
St. John’s	Newfoundland and Labrador	5–9 days
Regina	Saskatchewan	5–9 days
Saskatoon	Saskatchewan	5–9 days
Kitchener-Waterloo	Ontario	5–9 days
London	Ontario	5–9 days
Chicoutimi	Quebec	5–9 days