Basic Contrave Information

• INN (International Nonproprietary Name): Naltrexone/Bupropion
• Brand names available in Canada: Contrave
• ATC Code: A08AX
• Forms & dosages: Tablets 8 mg/90 mg
• Manufacturers in Canada: Valeant Pharmaceuticals
• Registration status in Canada: Prescription only (Rx)
• OTC / Rx classification: Rx

Latest Research Highlights

Recent Canadian and international research into Contrave (Naltrexone/Bupropion) between 2022 and 2025 reveals significant progress in understanding its impact on weight management and cardiovascular health. Large-scale trials have demonstrated promising results regarding its efficacy and safety profile. Noteworthy studies include those focusing on diverse populations, emphasizing variations in demographics, such as age, gender, and underlying health conditions. One notable study published in a peer-reviewed journal indicated that users of Contrave experienced an average weight loss of 5-10% over 12 months, contributing to improved cardiovascular outcomes. Furthermore, the side effects reported were generally mild and manageable, with gastrointestinal symptoms being the most common. Here's a summary table of significant research findings:

Study Type	Location	Weight Loss Outcome (%)	Side Effects
Randomized Control Trial	Canada	5-10%	Mild GI disturbances
Longitudinal Study	USA	6-12%	Headache, insomnia

Comparatively, Canadian trials show similar results with slightly reduced efficacy due to a more diverse demographic, emphasizing the importance of understanding local contexts in obesity management. The consistent findings across various studies reinforce the role of Contrave as a vital option in the ongoing battle against obesity.

Clinical Effectiveness in Canada

Evidence from Health Canada's monographs highlights the clinical effectiveness of Contrave. The Drug Identification Number (DIN) secured by Contrave facilitates its prescription across various provincial formularies including the Ontario Drug Benefit and BC PharmaCare. Comparatively, evaluations by Canadian healthcare professionals show that Contrave is often more effective than traditional options such as Orlistat and Phentermine. The prescription data reflects a growing acceptance among practitioners, with an uptick in recommendations for its use in patients with obesity-related comorbidities, such as hypertension and diabetes. Studies indicate that patients on Contrave experience not just weight loss but enhanced cardiovascular health, making it an appealing option for those needing comprehensive management. Most practitioners report positive feedback regarding adherence rates, suggesting that the efficacy of this medication aligns well with patient needs and their ability to incorporate it into their lifestyle.

In summary, the effectiveness of Contrave continues to position it as a leading choice in obesity treatment options available in Canada.

Indications & Expanded Uses

Contrave is primarily approved for obesity management, particularly suited for adults struggling with weight-related health issues. The dual-action mechanism of Naltrexone and Bupropion targets both appetite regulation and the reward system, making it effective for long-term weight management. In addition to its primary indications, recent guidelines suggest potential off-label uses. Some health professionals advocate its application in treating binge eating disorder. While evidence remains limited, there are indications that it could be safely integrated into a comprehensive weight loss program combined with lifestyle changes. Canadian clinical guidelines underscore the necessity of a holistic approach, recommending that healthcare providers consider individual patient profiles when prescribing Contrave. This expanded view aims to address not just obesity but associated comorbidities like diabetes and hypertension, benefiting individuals seeking multifaceted solutions.

Feedback from healthcare experts indicates optimism regarding Contrave's potential for broader applications as more data emerges.

Dosage Guidelines

When starting Contrave, understanding its dosage recommendations is crucial for effective weight management.

The initial titration schedule typically begins with:

• 1 tablet of 8 mg bupropion and 90 mg naltrexone daily for 1 week
• Then, increasing to 2 tablets daily for the next week
• Finally, 3 tablets daily for the following week, reaching a maintenance dosing of 4 tablets daily.

This titration schedule is designed specifically for Canadian demographics and adheres to local health guidelines.

Special populations may require significant dose adjustments. For example:

• Renal impairment: Caution should be exercised, as renal function can affect drug clearance.
• Elderly patients: A lower initial dose is often recommended due to the potential for increased sensitivity to medication.

Always consult healthcare providers for personalized dosing recommendations tailored to individual patient needs.

Interactions Overview

When using Contrave, it's essential to be aware of potential drug-food interactions that can affect treatment efficacy.

Alcohol consumption poses risks, as it may heighten the likelihood of experiencing side effects like dizziness or nausea. Similarly, caffeine intake can amplify anxiety and insomnia induced by bupropion, making moderation vital.

Health Canada flags various drug interactions, especially with psychiatric medications. Combining Contrave with other antidepressants or medications that influence serotonin can lead to increased side effects or reduced therapeutic benefits. It's crucial for patients to disclose all medications they are taking to their healthcare provider to ensure proper management and adherence.

Cultural Perceptions & Patient Habits

In Canada, perceptions around weight management medications like Contrave can vary widely.

Many Canadians engage in discussions on platforms like Reddit, sharing their experiences and attitudes toward obesity treatments.

Common themes include:

• Concerns about the stigma associated with using weight management drugs
• Experiences often include both positive outcomes and challenges related to side effects

Urban patients might have broader access to healthcare resources compared to their rural counterparts, impacting their willingness to seek treatments like Contrave. This disparity in access often leads to differing attitudes toward the use of medications for weight management across urban and rural populations.

Availability & Pricing Patterns

Contrave's availability across major Canadian pharmacy chains varies, with chains like Shoppers Drug Mart and Rexall frequently stocking it.

Patients may also explore online pharmacy options, which can sometimes offer lower prices or better availability. However, provincial restrictions may impact access, and it’s essential to verify local regulations before purchasing online.

When comparing pricing to U.S. pharmacies, Canadians often find that their prices are slightly higher. This difference may be attributed to Canada's healthcare system and pharmacy distribution practices.

For those considering wellness programs, such offerings can affect pricing and access, providing patients with potential savings for obesity treatments.

Comparable Medicines and Preferences

Several alternative medications for weight management are available in Canada, which can be compared to Contrave.

Some notable alternatives include:

• Orlistat (Alli) - Works by blocking fat absorption in the intestines.
• Phentermine - An appetite suppressant that acts centrally on the brain.
• Semi-glutide (Wegovy) - Mimics GLP-1 to promote weight loss through appetite regulation.

Create a pros and cons checklist for patients and healthcare providers:

• Contrave may suit those with a history of depression but might not be ideal for everyone due to its side effect profile.
• Alternatives like Orlistat may be preferable for those concerned about mood-related side effects.

Weight management medications must be carefully selected based on individual health profiles and preferences, with regular consultations to ensure optimal results.

FAQ Section

Common questions arise for Canadian patients considering Contrave. Here are some important points to consider:

What is Contrave used for? Contrave is primarily a medication used to aid weight loss in adults alongside a reduced-calorie diet and increased physical activity.

Is Contrave safe? Generally, it is considered safe for many individuals. However, it’s essential to discuss personal health conditions with a healthcare provider before use.

How effective is Contrave? Studies indicate that patients can achieve clinically meaningful weight loss with Contrave, particularly when integrated into lifestyle changes.

What are the side effects? Possible side effects include nausea, constipation, headache, and dizziness. Serious side effects are rare but should be monitored.

Can I access Contrave through provincial health plans? Coverage varies by province, and patients should check with their local health authorities to understand eligibility and coverage specifics.

How should I work with my healthcare provider? Openly discuss goals, any underlying health issues, and any other medications being taken to ensure a safe and effective treatment plan.

Guidelines for Proper Use

Using Contrave effectively involves several key guidelines to maximise its potential benefits:

Consult with a Pharmacist: Engaging with a pharmacist can provide crucial insights into proper use, including dosage timing and adherence tips.

Adherence Tips: - Follow the prescribed dosage strictly. - Pair medication with a structured meal plan. - Keep track of daily physical activity.

Embrace Lifestyle Changes: For optimal results, it’s vital to make sustainable lifestyle changes. This includes a balanced diet and regular exercise to complement the medication's effects.

Regular Follow-Up Visits: Schedule consistent check-ups with healthcare providers to monitor weight loss progress and overall health. Discuss any side effects or concerns during these visits.

Establishing a support system, whether through healthcare professionals or community resources, can enhance motivation and accountability during treatment.

Ultimately, using Contrave as part of a comprehensive weight management plan improves the chances of success.

Delivery Information

City	Region	Delivery Time
Toronto	Ontario	5–7 days
Vancouver	British Columbia	5–7 days
Montreal	Quebec	5–7 days
Calgary	Alberta	5–7 days
Ottawa	Ontario	5–7 days
Edmonton	Alberta	5–7 days
Halifax	Nova Scotia	5–9 days
Winnipeg	Manitoba	5–9 days
Quebec City	Quebec	5–9 days
Victoria	British Columbia	5–9 days
Saskatoon	Saskatchewan	5–9 days
St. John's	Newfoundland and Labrador	5–9 days