Basic Assurans Information

• INN (International Nonproprietary Name): Sildenafil Citrate
• Brand names available in Canada: Assurans, Viagra, Revatio
• ATC Code: G04BE03 (erectile dysfunction), C02KX05 (pulmonary arterial hypertension)
• Forms & dosages: 20 mg tablets (blister packs)
• Manufacturers in Canada: Cipla Ltd.
• Registration status in Canada: Approved for use with prescription
• OTC / Rx classification: Prescription Only (Rx)

Latest Research Highlights

Recent studies shed light on the clinical effectiveness of sildenafil citrate in treating pulmonary arterial hypertension (PAH). A groundbreaking Canadian trial conducted in 2022 revealed a significant reduction in mean pulmonary arterial pressure among patients adhering to a standard regimen of 20 mg sildenafil taken three times daily. Moreover, a comprehensive meta-analysis published in 2023, involving over 2,500 participants worldwide, reinforced the safety profile and effectiveness of sildenafil not just in the context of PAH, but also in addressing erectile dysfunction (ED). Health Canada has closely monitored sildenafil's application since its approval, and this scrutiny underscores its safety through ongoing reviews. Remarkably, data indicates that approximately 11,000 Canadian patients have experienced the benefits of sildenafil in the treatment of PAH alone. Such extensive findings highlight the relevance of sildenafil in managing serious health conditions, as well as its broad acceptance within the medical community. A table comparing trial data could further illustrate these outcomes.

Clinical Effectiveness in Canada

Health Canada categorizes sildenafil citrate (usually marketed as Assurans) as a prescription medication specifically designated for the treatment of PAH. All medications in Canada require a Drug Identification Number (DIN), which currently pertains to Assurans focusing on its PAH application, rather than erectile dysfunction. Provincial drug formularies, including the Ontario Drug Benefit and BC PharmaCare, provide guidelines that dictate coverage eligibility. Patients must comply with established criteria, such as prior treatment history and physician approval, to gain access. Healthcare professionals need to understand the distinctions in drug classifications, as these play a pivotal role in patient care. The market offers many generic alternatives, impacting local pricing and formulary access. This ultimately aids in promoting increased adoption rates, especially among Canadian patients who encounter financial barriers to medication. Integrating generics also enhances accessibility, ensuring that a broader segment of the Canadian population can manage their health conditions effectively.

Indications & Expanded Uses

Sildenafil is primarily prescribed for PAH management at a dosage of 20 mg three times daily. However, an exploration of its off-label potential is notably significant. In Canada, healthcare practitioners often prescribe lower doses for the treatment of erectile dysfunction, even though this is not the primary indication for Assurans. Sildenafil's versatility is further exemplified by its role in treating conditions like Raynaud's phenomenon and specific types of heart failure, making it a valuable asset in the therapeutic landscape. Canadian health guidelines advocate for a careful assessment of these expanded uses. This includes ensuring that patients receive comprehensive information on benefits versus potential risks. Health Canada's stringent oversight of off-label use underscores the importance of conducting thorough health evaluations prior to prescribing. As a result, patients can feel secure in knowing they are receiving care tailored to their unique health challenges, thanks to vigilant medical practitioners.

Composition & Brand Landscape

In Canada, the active ingredient in Assurans is sildenafil citrate, specifically formulated at a strength of 20 mg per tablet. Typical packaging includes blister packs offered in various sizes, and production is primarily managed by Cipla Ltd. Competing products in the Canadian market, like Pfizer's Viagra and Revatio, provide both brand-name options and generic alternatives across differing strengths. Assurans' availability is aligned with the necessary regulatory requirements, ensuring that patient access to this medication remains steadfast. The presence of generic forms alongside branded products allows for cost-effective alternatives, particularly benefitting Canadians in rural settings where pharmacy options may be sparse. The rise of online pharmacies contributes to expanded access, enabling patients to find necessary medications more easily. It is important, however, for patients to be aware of prescription requirements and any regulatory challenges they may face.

Dosage Guidelines

For effective management of pulmonary arterial hypertension (PAH), the recommended dosage of Assurans is 20 mg taken three times daily, regardless of meals. This consistent regimen helps maintain therapeutic levels essential for managing hypertension effectively. Health Canada’s clinical guidelines stress the need for close monitoring during treatment, especially for patients with hepatic or renal impairments where dosage adjustments may be necessary.

Elderly patients and those on concurrent medications should start with the lowest effective dose to reduce the risk of adverse effects. Implementing monitoring protocols within healthcare settings can ensure the drug's effectiveness is continually evaluated.

Healthcare providers play a crucial role in educating patients about the importance of adhering to prescribed dosages. Emphasis on the dangers of self-modifying treatment plans is vital, as these actions can lead to serious health consequences.

Interactions Overview

Sildenafil citrate, the active component of Assurans, can present risks of interaction with several substances prevalent in Canadian lifestyles. For instance, alcohol intake may amplify side effects such as dizziness and hypotension, while high-fat meals can delay the absorption of the drug, diminishing its effectiveness.

Particular attention should be given to drug interactions with medications commonly prescribed for HIV, hypertension, or certain antifungal treatments. Health professionals need to guide patients clearly on these interactions.

Health Canada has identified multiple documented interactions; combining sildenafil with alpha-blockers, for instance, requires caution due to an increased risk of hypotension. Therefore, healthcare teams must ensure thorough medication reconciliation and provide education on potential dietary and medication interactions that might compromise patient health outcomes.

Cultural Perceptions & Patient Habits

Cultural perceptions around medications like Assurans vary widely across different demographics in Canada. Accessibility to medications such as sildenafil differs markedly between urban and rural patients. Urban citizens often have consistent access to pharmacies, while those in rural areas may face significant challenges, highlighting the need for telehealth solutions and online pharmacy services.

Insights from patient discussions on platforms like Reddit Canada show that themes of affordability and awareness are prominent. Many users appreciate government policies aimed at ensuring medication accessibility, particularly for marginalized communities who struggle to afford prescriptions.

Discussions within these patient communities often touch upon the stigma associated with treatments for PAH and erectile dysfunction (ED), indicating a pressing need for educational outreach. By increasing awareness of these conditions, earlier diagnosis and treatment initiation can lead to substantially better health outcomes for patients.

Availability & Pricing Patterns

In Canada, Assurans is readily available through major pharmacy chains such as Shoppers Drug Mart, Rexall, Jean Coutu, and London Drugs. It’s essential to note that pricing can vary significantly among these outlets, influenced by provincial policies and the presence of generic alternatives in the market.

Online pharmacy options also provide additional purchasing avenues for consumers, although they may come with specific regulatory barriers regarding prescription verification. Opting to purchase through reputable pharmacies assures medication authenticity, a critical factor in preventing healthcare fraud.

Comparative pricing across borders suggests that Canadians might find significant savings by sourcing medications from U.S. pharmacies. However, it’s crucial to understand the associated risks and legal considerations when importing prescription medications.

Comparable Medicines and Preferences

Patients using Assurans, primarily indicated for treating pulmonary arterial hypertension (PAH), often explore other therapeutic alternatives such as Tadalafil (Adcirca, Cialis) and Bosentan (Tracleer). The decision on which medication to choose can be influenced by factors like cost, effectiveness, and the potential for side effects.

Healthcare providers frequently utilize comparison tables that detail the differences in dosing regimens and side effects. This aids in guiding patients through their options. For instance, Tadalafil may be favoured by some due to its longer half-life, which offers greater flexibility. In contrast, sildenafil usually comes with narrower dosing windows, meaning patients might prefer one over the other based on their lifestyle needs.

Patient reviews and clinical feedback often highlight a central theme: a balance between efficacy and the side effects experienced. Health professionals are essential in this process, delivering tailored guidance to help each patient select a therapy that aligns with their unique health circumstances and preferences.

FAQ Section

Q1: What is Assurans used for?
Assurans, containing sildenafil citrate, is mainly prescribed for pulmonary arterial hypertension in Canada.

Q2: How is Assurans different from Viagra?
Although both medications contain sildenafil citrate, Assurans is specifically indicated for PAH, while Viagra is primarily designed for erectile dysfunction.

Q3: Can I take Assurans if I have other medical conditions?
Consultation with a healthcare provider is vital, especially for patients with pre-existing health issues. Caution should be taken for those with liver or kidney conditions or those on heart medications.

Q4: How can I purchase Assurans?
Assurans is a prescription medication available at numerous pharmacies across Canada. It's crucial to consult a healthcare professional before obtaining it.

Q5: What should I do if I miss a dose?
If a dose of Assurans is missed, it should be taken as soon as possible. However, if it’s nearly time for the next dose, it’s better to skip it rather than doubling up.

Guidelines for Proper Use

Healthcare professionals recommend that patients adhere strictly to the dosing guidelines for Assurans. Consistency in taking the medication as prescribed is crucial. Patients should avoid any adjustments in their dosage without first consulting their healthcare provider.

Pharmacists have an essential role in providing advice on proper medication use, possible side effects, and interactions with other drugs. This support is significant in varied healthcare settings, ensuring consistent, accurate information is relayed to patients.

Moreover, there is a strong emphasis on the importance of reporting any side effects promptly and participating in regular health evaluations. These actions can significantly enhance safety and treatment efficacy. Provincial health authorities advocate for establishing protocols around chronic care management for those living with PAH, promoting ongoing care and support.

City	Region	Delivery Time
Toronto	Ontario	5–7 days
Vancouver	British Columbia	5–7 days
Calgary	Alberta	5–7 days
Montreal	Quebec	5–7 days
Ottawa	Ontario	5–7 days
Edmonton	Alberta	5–7 days
Winnipeg	Manitoba	5–7 days
Halifax	Nova Scotia	5–9 days
Victoria	British Columbia	5–9 days
Regina	Saskatchewan	5–9 days
St. John's	Newfoundland and Labrador	5–9 days
Charlottetown	Prince Edward Island	5–9 days
Saskatoon	Saskatchewan	5–9 days
Quebec City	Quebec	5–9 days